Description
Hudson’s integrated screening workcell is designed to provide quick and accurate profiling of ADME and toxicological properties of drug molecules. The basic system contains everything needed to support biochemical assays that measure physicochemical properties of drug molecules, such as solubility, lipophilicity, pKa and protein binding, and also supports PAMPA and CACO2 permeability assays. It also can measure a drug’s affinity towards key toxicological targets, such as hERG, and the various CYP metabolic enzymes.
The system is controlled by Hudson’s SoftLinx scheduling software, and comes with sample protocols for each of the included ADME/Tox methods. These can be easily modified, or more assays can be added to further customize your follow-up screening efforts. The system comes with a multi-mode reader that not only supports a wide range of protocols, but can also run your primary or secondary screens. This means that you can have your ADME/Tox profiling automatically carried out on hits found in these assays.